Design and characterization of calcium-free in-situ gel formulation based on sodium alginate and chitosan
作者： Linda Belhadji , Abdelkader HadjSadok , Nadji Moulai-Mostefa
DOI: 10.1080/03639045.2017.1408640
关键词: Calcium 、 Polymer 、 Viscosity 、 Chitosan 、 Composite number 、 Chemistry 、 Dynamic mechanical analysis 、 Rheology 、 Kinetics 、 Chromatography
摘要: AbstractThe aim of this study was to prepare and evaluate calcium-free sustained release drug delivery systems, based on the in-situ gelation oral suspensions containing chitosan, sodium alginate Ranitidine as model. The combined effects polymer concentrations their interactions rheological characteristics both gels and, kinetics were evaluated by using a central composite face-centered design. Rheological analysis showed that potentially stable, with viscosity increased 1000 times compared water. In addition, obtained consistent; storage modulus could reach values close 50 kPa when concentration greater than 7.5 g/100 mL chitosan fixed 0.5 g/100 mL. these conditions should have higher gastric residence time, in comparison standard emptying time (∼2 h). Evaluation in-vitro associati...
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