Pineal modulation of thymus and immune function in a seasonally breeding tropical rodent, Funambulus pennanti.
作者： C Haldar , Rajesh Singh , None
DOI: 10.1002/1097-010X(20010201)289:2<90::AID-JEZ2>3.0.CO;2-S
关键词: Lymphocyte 、 Spleen 、 Melatonin 、 Pinealectomy 、 Biology 、 Pineal gland 、 Internal medicine 、 Immune system 、 Endocrine gland 、 Hormone 、 Endocrinology
摘要: The immune system driven by cytokines is now known to be influenced various other endocrine glands and its hormones. Results of the present study indicate a bidirectional relation between pineal–thymus axis status an Indian tropical rodent, Funambulus pennanti, during winter months (reproductive inactive phase), when it faces maximum challenges from nature. Pinealectomy reproductive phase inhibited thymus spleen functions, which resulted in significant changes leukocyte lymphocyte counts T-cell–mediated function (measured terms delayed-type hypersensitivity response oxazolone). Blastogenic responses lymphoid cells (thymocytes, splenocytes, lymph node cells) also decreased following ablation pineal gland. To check definite role gland we injected melatonin into pinealectomized squirrels, suppressed was significantly restored. Neuroendocrine control on histocompatible tissues this seasonal breeder, F. suggests adaptive mechanism for survival zone. J. Exp. Zool. 289:90–98, 2001. © 2001 Wiley-Liss, Inc.
sci-hub.se 参考文章(27)
SUSANNA CUNNINGHAM-RUNDLES, JOHN A. HANSEN, BO DUPONT, Lymphocyte Transformation in Vitro in Response to Mitogens and Antigens Clinical Immunobiology. ,vol. 3, pp. 151- 194 ,(1976) , 10.1016/B978-0-12-070003-5.50014-0
C. Haldar, D. Häussler, D. Gupta, Chapter 42: Response of CFU-GM (colony forming units for granulocytes and macrophages) from intact and pinealectomized rat bone marrow to murine recombinant interleukin-3 (rI1-3), recombinant granulocyte-macrophage colony stimulating factor (rGM-CSF) and human recombinant erythropoietin (rEPO) Progress in Brain Research. ,vol. 91, pp. 323- 325 ,(1992) , 10.1016/S0079-6123(08)62349-3
Thomas H. Champney, David N. McMurray, Spleen Morphology and Lymphoproliferative Activity in Short Photoperiod Exposed Hamsters Springer, Boston, MA. pp. 219- 223 ,(1991) , 10.1007/978-1-4615-3756-4_24
Nir I, Biorhythms and the biological clock involvement of melatonin and the pineal gland in life and disease. Biomedical and Environmental Sciences. ,vol. 8, pp. 90- 105 ,(1995)
Maria G. Gonzalez‐Haba, Sofia Garcia‐Mauriño, Juan R. Calvo, Raimundo Goberna, Juan M. Guerrero, High-affinity binding of melatonin by human circulating T lymphocytes (CD4+). The FASEB Journal. ,vol. 9, pp. 1331- 1335 ,(1995) , 10.1096/FASEBJ.9.13.7557023
A. Conti, Valeria Covacci, Georges J. M. Maestroni, Hematopoietic Rescue via T-Cell-dependent, Endogenous Granulocyte-Macrophage Colony-stimulating Factor Induced by the Pineal Neurohormone Melatonin in Tumor-bearing Mice Cancer Research. ,vol. 54, pp. 2429- 2432 ,(1994)
A L Goldstein, N R Hall, J P McGillis, Circadian rhythm of thymosin-alpha 1 in normal and thymectomized mice. Journal of Immunology. ,vol. 131, pp. 148- 151 ,(1983)
K Kumagai, K Itoh, T Kawate, T Abo, Studies on the bioperiodicity of the immune response. I. Circadian rhythms of human T, B, and K cell traffic in the peripheral blood Journal of Immunology. ,vol. 126, pp. 1360- 1363 ,(1981)
A. Lewiński, P. Zelazowski, E. Sewerynek, G. Zerek-Mełeń, M. Szkudliński, E. Zelazowska, Melatonin-induced suppression of human lymphocyte natural killer activity in vitro Journal of Pineal Research. ,vol. 7, pp. 153- 164 ,(1989) , 10.1111/J.1600-079X.1989.TB00663.X
Anna Stefano, Luana Paulesu, Inhibitory effect of melatonin on production of IFNγ or TNFα in peripheral blood mononuclear cells of some blood donors Journal of Pineal Research. ,vol. 17, pp. 164- 169 ,(1994) , 10.1111/J.1600-079X.1994.TB00128.X