Chapter 42: Response of CFU-GM (colony forming units for granulocytes and macrophages) from intact and pinealectomized rat bone marrow to murine recombinant interleukin-3 (rI1-3), recombinant granulocyte-macrophage colony stimulating factor (rGM-CSF) and human recombinant erythropoietin (rEPO)
作者： C. Haldar , D. Häussler , D. Gupta
DOI: 10.1016/S0079-6123(08)62349-3
关键词: Molecular biology 、 Cytokine 、 Internal medicine 、 Endocrinology 、 Pinealectomy 、 Granulocyte macrophage colony-stimulating factor 、 Pineal gland 、 CFU-GM 、 Recombinant Interleukin 、 Biology 、 Recombinant DNA 、 Colony-forming unit
摘要: The present study provides evidence, for the first time, of a role pineal gland in proliferation CFU-GM under influence different cytokines. degree colony formation cytokine groups was evaluated after 24 h, 3, 7 and 10 days. growth type bone marrow cell cultures slows 10th day ceases 14th incubation. results show that rGM-CSF combination with rI1-3 rEPO stimulate granulocytes macrophages. A 50% general reduction number noted pinealectomy group. Their pattern response to cytokines similar intact It is suggested activity has physiological important aspects host defence mechanisms, such as CFU-GM.
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