Mechanisms of resistant of herpesviruses: comparison of the effectiveness of different cell types in mediating antibody-dependent cell-mediated cytotoxicity.

摘要: Enriched populations of polymorphonuclear leukocytes (PMN) and macrophages obtained from the mammary gland granulocytes (PBG) lymphocytes (PBL) prepared peripheral blood same animal were compared for their ability to mediate antibody-dependent cell cytotoxocity against antibody-sensitized infectious bovine rhinotracheitis virus-infected target cells (IBR-GBK) chicken erythrocyte targest (CRBC). The order effectiveness was PMN leads PBG PBL. reason why (86% PMN) less than 50% as active (99% explored discussed. findings that more effective on a cell-to-cell basis, required antiserum sensitize cytotoxicity, destroyed IBR-GBK faster completely other types could mean may be type most importnat in causing early recovery herpesvirus infections.