Combined effects on tumor growth and metastasis by anti-estrogenic and antiangiogenic therapies in MMTV-neu mice.

摘要: Breast tumor growth and metastasization are both hormone-sensitive angiogenesis-dependent. Recent work carried out in our laboratory on a transgenic model of breast cancer displaying many similarities to its human counterpart, has shown that liposome-mediated angiostatin cDNA delivery partially inhibits local metastatic growth. However, it is now recognized anti-angiogenesis strategy alone cannot completely arrest spread, this led the suggestion approaches based different molecular mechanisms could usefully be combined. In present work, we investigated whether tamoxifen, classical antiestrogen agent widely used therapy, improve results obtained with alone. Further reduction was achieved combined regimen respect or tamoxifen alone, while, as expected, no detected either group. We therefore conclude combination angiogenesis inhibitors drugs might useful humans other associations between conventional gene transfer-mediated therapy worth investigating will soon become important components anticancer therapy.