Embryonal central neuroepithelial tumors: Current concepts and future challenges

摘要: While the embryonal central neuroepithelial tumors present complex conceptual and clinical problems, advances in cell type identification by special neurohistological, immunohisto- immunocytochemical techniques have permitted discrimination of distinct cytomorphogenetic entities. These are based part on their resemblance to normal phases neurocytogenesis. Four these tumors, medulloepithelioma, desmoplastic infantile ganglioglioma, pineoblastoma medulloblastoma, designated as multipotential light capacity undergo divergent differentiation. Cytomorphogenetic, experimental data implicate fetal neural targets for transformation raise possibility that aberrant developmental regulatory mechanisms may contribute biologic behavior tumors. Growth factors some neuroregulatory neurotransmitters (such serotonin) known act modulators neuromorphogenesis. They could play a role hypothesis neoplasms either be modified fuctional receptor responses or result from abnormal substances. Future challenges include 1) definition new entities subgroups currently defined forms CNS presence specific growth neurotransmitters, receptors, 2) characterization neoplastic mediating any modulatory presently maturation potential 3) further developmental, stage-specific might operative