The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis.
作者： Kristiina Nordfors , Joonas Haapasalo , Miikka Korja , Anssi Niemelä , Jukka Laine
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摘要: Background Medulloblastomas (MBs) and supratentorial primitive neuroectodermal tumours (PNETs) are the most common highly aggressive paediatric brain tumours. In spite of extensive research on these tumours, there only few known biomarkers or therapeutic target proteins, prognosis patients with remains poor. Our aim was to investigate whether carbonic anhydrases (CAs), enzymes commonly overexpressed in various including glioblastomas oligodendrogliomas, present MBs PNETs, their expression can be correlated patient prognosis.
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