Determination of piracetam in human plasma and urine by liquid chromatography
作者： K. Louchahi , M. Tod , P. Bonnardel , O. Petitjean
DOI: 10.1016/0378-4347(94)00448-E
关键词: High-performance liquid chromatography 、 Urine 、 Blood plasma 、 Absorbance 、 Half-life 、 Pharmacokinetics 、 Quantitative analysis (chemistry) 、 Chromatography 、 Piracetam 、 Chemistry
摘要: A method for the determination of piracetam in human plasma and urine by liquid chromatography with absorbance detection at 206 nm isocratic elution is proposed. The assay involved a liquid-liquid extraction into hexane-2-propanol pH 9.2. calibration graphs were linear range 3-40 mg/l 100-2000 urine. Bias was negligible coefficients variation less than 10% throughout working except 100 limits quantification 3 reliably used pharmacokinetic studies humans after administration 800 mg per os.
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