Combination of anti-kir and anti-ctla-4 antibodies to treat cancer

作者: Jon Wigginton , Ashok K. Gupta , Pascale Andre , Su Young Kim , Robert F. Graziano

DOI:

关键词: Clinical treatmentAntibodyCancerImmunologyAnti ctla 4Medicine

摘要: Provided are methods for clinical treatment of cancer (e.g., solid tumors or hematological malignancies) using an anti-KIR antibody in combination with anti-CTLA-4 antibody.

参考文章(14)
Peter Andreas Nicolai Reumert Wagtmann, Joakim Glamann, Francois Romagné, Anti-kir combination treatments and methods ,(2006)
Theodora Voskoglou-Nomikos, Lesley Seymour, Joseph L. Pater, Clinical Predictive Value of the in Vitro Cell Line, Human Xenograft, and Mouse Allograft Preclinical Cancer Models Clinical Cancer Research. ,vol. 9, pp. 4227- 4239 ,(2003)
María Virtudes Céspedes, Isolda Casanova, Matilde Parreño, Ramón Mangues, Mouse models in oncogenesis and cancer therapy. Clinical & Translational Oncology. ,vol. 8, pp. 318- 329 ,(2006) , 10.1007/S12094-006-0177-7
Francois Romagné, Pascale André, Pieter Spee, Stefan Zahn, Nicolas Anfossi, Laurent Gauthier, Marusca Capanni, Loredana Ruggeri, Don M. Benson, Bradley W. Blaser, Mariella Della Chiesa, Alessandro Moretta, Eric Vivier, Michael A. Caligiuri, Andrea Velardi, Nicolai Wagtmann, Preclinical characterization of 1-7F9, a novel human anti–KIR receptor therapeutic antibody that augments natural killer–mediated killing of tumor cells Blood. ,vol. 114, pp. 2667- 2677 ,(2009) , 10.1182/BLOOD-2009-02-206532
James E. Talmadge, Rakesh K. Singh, Isaiah J. Fidler, Avraham Raz, Murine models to evaluate novel and conventional therapeutic strategies for cancer. American Journal of Pathology. ,vol. 170, pp. 793- 804 ,(2007) , 10.2353/AJPATH.2007.060929
Greg M. Thurber, Michael M. Schmidt, K. Dane Wittrup, Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Advanced Drug Delivery Reviews. ,vol. 60, pp. 1421- 1434 ,(2008) , 10.1016/J.ADDR.2008.04.012
Robert A Beckman, Louis M. Weiner, Hugh M. Davis, Antibody constructs in cancer therapy: protein engineering strategies to improve exposure in solid tumors. Cancer. ,vol. 109, pp. 170- 179 ,(2007) , 10.1002/CNCR.22402
Stephen I. Rudnick, Gregory P. Adams, Affinity and avidity in antibody-based tumor targeting. Cancer Biotherapy and Radiopharmaceuticals. ,vol. 24, pp. 155- 161 ,(2009) , 10.1089/CBR.2009.0627
F. Stephen Hodi, Steven J. O'Day, David F. McDermott, Robert W. Weber, Jeffrey A. Sosman, John B. Haanen, Rene Gonzalez, Caroline Robert, Dirk Schadendorf, Jessica C. Hassel, Wallace Akerley, Alfons J.M. van den Eertwegh, Jose Lutzky, Paul Lorigan, Julia M. Vaubel, Gerald P. Linette, David Hogg, Christian H. Ottensmeier, Celeste Lebbé, Christian Peschel, Ian Quirt, Joseph I. Clark, Jedd D. Wolchok, Jeffrey S. Weber, Jason Tian, Michael J. Yellin, Geoffrey M. Nichol, Axel Hoos, Walter J. Urba, Improved Survival with Ipilimumab in Patients with Metastatic Melanoma. The New England Journal of Medicine. ,vol. 363, pp. 711- 723 ,(2010) , 10.1056/NEJMOA1003466
A ASCIERTO PAOLO, M MARINCOLA FRANCESCO, RIBAS ANTONI, None, Anti-CTLA4 monoclonal antibodies: the past and the future in clinical application. Journal of Translational Medicine. ,vol. 9, pp. 196- 196 ,(2011) , 10.1186/1479-5876-9-196