Pd-1-binding molecules and methods of use thereof

摘要: The present invention is directed to selected anti-PD-1 antibodies capable of binding both cynomolgus monkey PD-1 and human : mAb 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15, humanized chimeric versions such antibodies. additionally pertains -binding molecules that comprise fragments antibodies, immunocongugates, bispecific molecules, including diabodies, BiTEs, etc., (i) fragments, (ii) a domain an epitope molecule involved in regulating immune check point on the surface cells. also methods using bind for stimulating responses, as well detecting PD-1.