The Effects of Kisspeptin on Gonadotropin Release in Non-human Mammals

摘要: The Kiss1 gene encodes a 145-amino acid pre-peptide, kisspeptin, which is cleaved into smaller peptides of 54, 14, 13, and 10 amino acids. This chapter reviews in detail the effects kisspeptin on gonadotropin secretion non-human mammals. Studies kisspeptin’s have included both acute chronic administration regimens via number routes. Acute stimulates wide range species mammals, including rats, mice, hamsters, sheep, pigs, goats, cows, horses, monkeys. In general, stimulatory effect treatment more pronounced for LH than FSH secretion. Kisspeptin thought to exert its release stimulation GnRH from hypothalamus, since pre-­administration antagonist prevents Although receptor also expressed anterior pituitary cells some species, incubation with high concentrations can stimulate vitro release, contribution direct be negligible vivo. Continuous results reduced sensitivity species. desensitization occur at level receptor, response gland exogenous maintained. Overall, findings discussed this are invaluable understanding reproductive role potential therapeutic uses fertility disorders.