Sustained Induction of Heme Oxygenase-1 in the Traumatized Spinal Cord

摘要: Oxidative stress contributes to secondary injury after spinal cord trauma. Among the consequences of oxidative is induction heme oxygenase-1 (HO-1), an inducible isozyme that metabolizes iron, biliverdin, and carbon monoxide. Here we examine HO-1 in hemisected cord, a model results reproducible degeneration ipsilateral white matter. was induced microglia macrophages from 24 h at least 42 days injury. Within first week injury, both gray Thereafter, expression limited degenerating fiber tracts. HSP70, heat shock protein mainly by presence denatured proteins, consistently colocalized with macrophages. This study demonstrates long-term HSP70 traumatic association between Wallerian degeneration. White matter characterized phagocytosis cellular debris remodeling surviving tissue. metabolism, synthesis, turnover proteins. Thus, sustained suggests tissue ongoing process, lasting 6 weeks perhaps even longer.