Targeted Maintenance Treatment in Schizophrenia

作者: Robert W. Buchanan , William T. Carpenter

DOI: 10.2165/00023210-199605040-00002

关键词: SchizophreniaIntensive care medicineNegative symptomNeurologyAntipsychoticPharmacotherapyMedicineTardive dyskinesiaPsychopharmacologyPharmacology (medical)Psychiatry and Mental healthClinical neurology

摘要: Summary The development of targeted maintenance treatment with anti psychotics arose out the recognition that, despite its efficacy for preventing relapses schizophrenia, standard was associated a number actual and potential disadvantages. Targeted designed to circumvent these disadvantages by decreasing total antipsychotic exposure while maintaining prophylactic benefit treatment. has been shown be effective in reducing may negative symptoms. However, use is an increase relapse hospitalisation rates. These increased rates limit recommended approach selected patient populations.

参考文章(15)
Adolf Pietzcker, Wolfgang Gaebel, Wolfgang Köpcke, Michael Linden, Peter Müller, Franz Müller-Spahn, Joachim Tegeler, Intermittent versus maintenance neuroleptic long-term treatment in Schizophrenia—2-year results of a German multicenter study Journal of Psychiatric Research. ,vol. 27, pp. 321- 339 ,(1993) , 10.1016/0022-3956(93)90059-B
Marvin I. Herz, Intermittent vs Maintenance Medication in Schizophrenia Archives of General Psychiatry. ,vol. 48, pp. 333- 339 ,(1991) , 10.1001/ARCHPSYC.1991.01810280049007
J. M. Kane, S. R. Marder, Psychopharmacologic Treatment of Schizophrenia Schizophrenia Bulletin. ,vol. 19, pp. 287- 302 ,(1993) , 10.1093/SCHBUL/19.2.287
John Kane, Clozapine for the Treatment-Resistant Schizophrenic Archives of General Psychiatry. ,vol. 45, pp. 789- 796 ,(1988) , 10.1001/ARCHPSYC.1988.01800330013001
J. Bustillo, R. W. Buchanan, W. T. Carpenter, Prodromal symptoms vs. early warning signs and clinical action in schizophrenia Schizophrenia Bulletin. ,vol. 21, pp. 553- 559 ,(1995) , 10.1093/SCHBUL/21.4.553
E. Goldberg, Akinesia, Tardive Dysmentia, and Frontal Lobe Disorder in Schizophrenia Schizophrenia Bulletin. ,vol. 11, pp. 255- 263 ,(1985) , 10.1093/SCHBUL/11.2.255
R. M.G. Norman, A. K. Malla, Prodromal Symptoms of Relapse in Schizophrenia: A Review Schizophrenia Bulletin. ,vol. 21, pp. 527- 539 ,(1995) , 10.1093/SCHBUL/21.4.527
R. W. Buchanan, Clozapine: Efficacy and Safety Schizophrenia Bulletin. ,vol. 21, pp. 579- 591 ,(1995) , 10.1093/SCHBUL/21.4.579