Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
作者： Maria Themeli , Christopher C Kloss , Giovanni Ciriello , Victor D Fedorov , Fabiana Perna
DOI: 10.1038/NBT.2678
关键词: Cancer stem cell 、 Cancer research 、 Stem cell 、 Cytotoxic T cell 、 Antigen-presenting cell 、 Induced stem cells 、 Biology 、 Induced pluripotent stem cell 、 Natural killer T cell 、 IL-2 receptor 、 Immunology
摘要: … Genetic engineering of T lymphocytes to express CARs has recently emerged as a promising approach to rapidly generate tumor-targeted T cells endowed with enhanced anti-tumor …
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Dick J. Pang, Joana F. Neves, Nital Sumaria, Daniel J. Pennington, Understanding the complexity of γδ T-cell subsets in mouse and human Immunology. ,vol. 136, pp. 283- 290 ,(2012) , 10.1111/J.1365-2567.2012.03582.X
R H Collins, O Shpilberg, W R Drobyski, D L Porter, S Giralt, R Champlin, S A Goodman, S N Wolff, W Hu, C Verfaillie, A List, W Dalton, N Ognoskie, A Chetrit, J H Antin, J Nemunaitis, Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. Journal of Clinical Oncology. ,vol. 15, pp. 433- 444 ,(1997) , 10.1200/JCO.1997.15.2.433
James N. Kochenderfer, Mark E. Dudley, Steven A. Feldman, Wyndham H. Wilson, David E. Spaner, Irina Maric, Maryalice Stetler-Stevenson, Giao Q. Phan, Marybeth S. Hughes, Richard M. Sherry, James C. Yang, Udai S. Kammula, Laura Devillier, Robert Carpenter, Debbie-Ann N. Nathan, Richard A. Morgan, Carolyn Laurencot, Steven A. Rosenberg, B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells Blood. ,vol. 119, pp. 2709- 2720 ,(2012) , 10.1182/BLOOD-2011-10-384388
PATRICIA M. GRAMBSCH, TERRY M. THERNEAU, Proportional hazards tests and diagnostics based on weighted residuals Biometrika. ,vol. 81, pp. 515- 526 ,(1994) , 10.1093/BIOMET/81.3.515
John C. Markley, Michel Sadelain, IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell–mediated rejection of systemic lymphoma in immunodeficient mice Blood. ,vol. 115, pp. 3508- 3519 ,(2010) , 10.1182/BLOOD-2009-09-241398
Jean-Jacques Fournié, Hélène Sicard, Mary Poupot, Christine Bezombes, Amandine Blanc, François Romagné, Loic Ysebaert, Guy Laurent, What lessons can be learned from γδ T cell-based cancer immunotherapy trials? Cellular & Molecular Immunology. ,vol. 10, pp. 35- 41 ,(2013) , 10.1038/CMI.2012.39
Renier J. Brentjens, Jean-Baptiste Latouche, Elmer Santos, Francesc Marti, Michael C. Gong, Clay Lyddane, Philip D. King, Steven Larson, Mark Weiss, Isabelle Rivière, Michel Sadelain, Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. Nature Medicine. ,vol. 9, pp. 279- 286 ,(2003) , 10.1038/NM827
Eirini P Papapetrou, Gabsang Lee, Nirav Malani, Manu Setty, Isabelle Riviere, Laxmi M S Tirunagari, Kyuichi Kadota, Shoshannah L Roth, Patricia Giardina, Agnes Viale, Christina Leslie, Frederic D Bushman, Lorenz Studer, Michel Sadelain, Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells Nature Biotechnology. ,vol. 29, pp. 73- 78 ,(2011) , 10.1038/NBT.1717
Igor I. Slukvin, Deciphering the hierarchy of angiohematopoietic progenitors from human pluripotent stem cells Cell Cycle. ,vol. 12, pp. 720- 727 ,(2013) , 10.4161/CC.23823
Raul Vizcardo, Kyoko Masuda, Daisuke Yamada, Tomokatsu Ikawa, Kanako Shimizu, Shin-ichiro Fujii, Haruhiko Koseki, Hiroshi Kawamoto, Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells Cell Stem Cell. ,vol. 12, pp. 31- 36 ,(2013) , 10.1016/J.STEM.2012.12.006