Essential Functions for ID Proteins at Multiple Checkpoints in Invariant NKT Cell Development
作者： Mihalis Verykokakis , Veena Krishnamoorthy , Antonio Iavarone , Anna Lasorella , Mikael Sigvardsson
关键词: Cell 、 Adoptive cell transfer 、 Natural killer T cell 、 Lymphopoiesis 、 Transcription factor 、 Cell growth 、 Interleukin 4 、 Biology 、 Immunology 、 Cell biology 、 Innate lymphoid cell
摘要: Invariant NKT (iNKT) cells display characteristics of both adaptive and innate lymphoid (ILCs). Like other ILCs, iNKT constitutively express ID proteins, which antagonize the E protein transcription factors that are essential for lymphocyte development. However, unlike ID2 is not thymic cell In this study, we demonstrated ID3 redundantly promoted lineage specification involving induction signature factor PLZF was critical development TBET-dependent NKT1 cells. contrast, limited numbers by enforcing postselection checkpoint in conventional thymocytes. Therefore, show innate-like requirements proteins at distinct checkpoints during
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