The eukaryotic genome as an RNA machine

作者: P. P. Amaral , M. E. Dinger , T. R. Mercer , J. S. Mattick

DOI: 10.1126/SCIENCE.1155472

关键词: EukaryoteRNARegulation of gene expressionNon-coding RNAGeneticsProtein biosynthesisGenomeComputational biologyTranscription (biology)BiologyDevelopmental biology

摘要: The past few years have revealed that the genomes of all studied eukaryotes are almost entirely transcribed, generating an enormous number non-protein-coding RNAs (ncRNAs). In parallel, it is increasingly evident many these regulatory functions. Here, we highlight recent advances illustrate diversity ncRNA control genome dynamics, cell biology, and developmental programming.

参考文章(72)
Martin C Frith, Alistair R Forrest, Ehsan Nourbakhsh, Ken C Pang, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Timothy L Bailey, Sean M Grimmond, PLoS Genetics EIC Wayne Frankel, The abundance of short proteins in the mammalian proteome PLOS Genetics. ,vol. 2, pp. 515- 528 ,(2006) , 10.1371/JOURNAL.PGEN.0020052
H. D. Folco, A. L. Pidoux, T. Urano, R. C. Allshire, Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres Science. ,vol. 319, pp. 94- 97 ,(2008) , 10.1126/SCIENCE.1150944
J. A. Nickerson, G. Krochmalnic, K. M. Wan, S. Penman, Chromatin architecture and nuclear RNA. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 177- 181 ,(1989) , 10.1073/PNAS.86.1.177
S. R. Viswanathan, G. Q. Daley, R. I. Gregory, Selective blockade of microRNA processing by Lin28. Science. ,vol. 320, pp. 97- 100 ,(2008) , 10.1126/SCIENCE.1154040
M. Clamp, B. Fry, M. Kamal, X. Xie, J. Cuff, M. F. Lin, M. Kellis, K. Lindblad-Toh, E. S. Lander, Distinguishing protein-coding and noncoding genes in the human genome Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 19428- 19433 ,(2007) , 10.1073/PNAS.0709013104
Marc Bühler, Danesh Moazed, Transcription and RNAi in heterochromatic gene silencing Nature Structural & Molecular Biology. ,vol. 14, pp. 1041- 1048 ,(2007) , 10.1038/NSMB1315
Ee Sin Chen, Ke Zhang, Estelle Nicolas, Hugh P. Cam, Martin Zofall, Shiv I. S. Grewal, Cell cycle control of centromeric repeat transcription and heterochromatin assembly Nature. ,vol. 451, pp. 734- 737 ,(2008) , 10.1038/NATURE06561
R Lin, S Maeda, C Liu, M Karin, T S Edgington, A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene. ,vol. 26, pp. 851- 858 ,(2007) , 10.1038/SJ.ONC.1209846
Jamy C. Peng, Gary H. Karpen, H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability Nature Cell Biology. ,vol. 9, pp. 25- 35 ,(2007) , 10.1038/NCB1514
M. Sone, T. Hayashi, H. Tarui, K. Agata, M. Takeichi, S. Nakagawa, The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons Journal of Cell Science. ,vol. 120, pp. 2498- 2506 ,(2007) , 10.1242/JCS.009357