T-Cell Development and Function: Relationship to Immunodeficiencies

摘要: Recent advances in knowledge about the phenotypical and functional aspects of T-cell ontogeny, as well molecular events involved this process, promise to be considerable help understanding several human immunodeficiency disorders. The earlier steps intrathymic differentiation have recently been shown involve expression surface molecules, such receptors for interleukin-2 (IL-2) T11 determinant, which might paramount importance inductive signals (von Boehmer et al. 1985; Meuer 1984). These would induce, within thymic environment, further maturation early thymocytes. stepwise these cells is marked by acquisition discrete markers rearrangements genes encoding receptor structures. transition from (stage I) common II) thymocytes appearance T6 determinant rearrangement (TCR) beta-chain (Royer stage III characterized disappearance T6, TCR alpha-chain genes, TCRs bound T3 molecule (T3Ti complex) 1984; Collins 1985). Virtually nothing known role receptor-like structure encoded gamma gene (Saito possibility that self-recognition major histocompatibility complex (MHC) during earliest stages interesting (Raulet