Genes encoding the Ti β subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression
作者： Hans Dieter Royer , Oreste Acuto , Marina Fabbi , Richard Tizard , Kuzhalmannam Ramachandran
DOI: 10.1016/0092-8674(84)90003-5
关键词:
摘要: To obtain further information about the ontogeny of T-cell antigen/MHC receptor, a Ti beta subunit cDNA probe and heteroantisera specific for alpha subunits were utilized to characterize human T-lineage cells. Analysis thymic tumors normal thymocytes at both DNA protein levels demonstrates that gene rearrangement is evident in stage II (T11+T6+T3-) III (T11+T6-T3+), but not I (T11+T6-T3-) thymocytes. In contrast, surface expression molecules exclusively restricted Thus characterized by an orderly series differentiation steps wherein precedes T3-Ti molecular complex.
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