Cross-dehydrogenative coupling and oxidative-amination reactions of ethers and alcohols with aromatics and heteroaromatics.

摘要: Cross-dehydrogenative coupling (CDC) is a process in which, typically, C–C bond formed at the expense of two C–H bonds, either catalyzed by metals or other organic compounds, via uncatalyzed processes. In this perspective, we present various modes bond-activation sp3 centers adjacent to ether oxygen atoms, followed formation with aromatic systems as well heteroaromatic systems. C–N bond-formation NH-containing heteroaromatics, leading hemiaminal ethers, also an event that can occur analogously formation, but and N–H bonds. A large variety ether-forming reactions have recently appeared literature perspective includes complementary chemistry. addition, participation bonds alcohols such processes described. Facile access wide range compounds be attained through these processes, rendering useful for synthetic applications Csp3 activations.