Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling
作者： Daniel J. Gough , Nicole L. Messina , Christopher J.P. Clarke , Ricky W. Johnstone , David E. Levy
DOI: 10.1016/J.IMMUNI.2012.01.011
关键词: NFKB1 、 Biology 、 Interferon type I 、 Interferon 、 Crosstalk (biology) 、 Signal transduction 、 Cellular differentiation 、 Downregulation and upregulation 、 Immunology 、 Transcription factor
摘要: Interferons (IFNs) were discovered as cytokines induced during and protecting from viral infection. They have been documented to play essential roles in numerous physiological processes beyond antiviral antimicrobial defense, including immunomodulation, cell cycle regulation, survival, differentiation. Recent data also uncovered a potentially darker side IFN, inflammatory diseases, such autoimmunity diabetes. IFN can effects the absence of acute infection, highlighting a physiologic role for constitutive IFN. Type I IFNs are constitutively produced at vanishingly low quantities yet exert profound effects, mediated part through modulation signaling intermediates required responses diverse cytokines. We review evidence yin-yang function its modulating crosstalk between multiple by both feedforward feedback regulation common postulate homeostatic tonic
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