Distinct Clinical Courses in Type 1 Diabetes Mellitus Induced by Peg-interferon-.ALPHA. Treatment for Chronic Hepatitis C
作者： Masanori Yamazaki , Ai Sato , Teiji Takeda , Mitsuhisa Komatsu
DOI: 10.2169/INTERNALMEDICINE.49.2656
关键词:
摘要: We report two cases of type 1 diabetes mellitus (T1DM) which developed after interferon (IFN) therapy for chronic hepatitis C. The patients had experienced abrupt hyperglycemia with positive anti-glutamic acid decarboxylase antibodies, resulting in initiation insulin therapy. In one case, could be discontinued because endogenous secretion was preserved at the onset and pancreatic β cell function recovered thereafter. other case Hashimoto's thyroiditis Sjogren's syndrome, continuation necessary blood glucose levels were unstably controlled. Lasting autoimmunity superior to immunosuppressive mechanism may associated distinct clinical courses these cases.
sci-hub.se 参考文章(14)
G. Aleph Prieto, Yvonne Rosenstein, Oestradiol potentiates the suppressive function of human CD4+ CD25+ regulatory T cells by promoting their proliferation Immunology. ,vol. 118, pp. 58- 65 ,(2006) , 10.1111/J.1365-2567.2006.02339.X
P. Fabris, A. Floreani, G. Tositti, D. Vergani, F. De Lalla, C. Betterle, Type 1 diabetes mellitus in patients with chronic hepatitis C before and after interferon therapy. Alimentary Pharmacology & Therapeutics. ,vol. 18, pp. 549- 558 ,(2003) , 10.1046/J.1365-2036.2003.01681.X
L.-K. Chen, Y.-C. Chou, S.-T. Tsai, S.-J. Hwang, S.-D. Lee, Hepatitis C virus infection-related Type 1 diabetes mellitus Diabetic Medicine. ,vol. 22, pp. 340- 343 ,(2005) , 10.1111/J.1464-5491.2005.01412.X
Teruo Shiba, Yoshihiro Morino, Kazumi Tagawa, Hitoshi Fujino, Tadao Unuma, Onset of diabetes with high titer anti-GAD antibody after IFN therapy for chronic hepatitis Diabetes Research and Clinical Practice. ,vol. 30, pp. 237- 241 ,(1995) , 10.1016/0168-8227(95)01188-9
Beate Karges, Ivana Durinovic-Belló, Eberhard Heinze, Klaus-Michael Debatin, Bernhard Boehm, Wolfram Karges, Immunological mechanisms associated with long-term remission of human type 1 diabetes Diabetes-metabolism Research and Reviews. ,vol. 22, pp. 184- 189 ,(2006) , 10.1002/DMRR.600
Gunnel Nordmark, Gunnar V Alm, Lars Rönnblom, Mechanisms of Disease: primary Sjögren's syndrome and the type I interferon system Nature Reviews Rheumatology. ,vol. 2, pp. 262- 269 ,(2006) , 10.1038/NCPRHEUM0173
Masako Waguri, Toshiaki Hanafusa, Naoto Itoh, Akihisa Imagawa, Jun-ichiro Miyagawa, Sumio Kawata, Norio Kono, Masamichi Kuwajima, Yuji Matsuzawa, Occurrence of IDDM during interferon therapy for chronic viral hepatitis. Diabetes Research and Clinical Practice. ,vol. 23, pp. 33- 36 ,(1994) , 10.1016/0168-8227(94)90124-4
C. Betterle, P. Fabris, R. Zanchetta, B. Pedini, G. Tositti, E. Bosi, F. de Lalla, Autoimmunity against pancreatic islets and other tissues before and after interferon-alpha therapy in patients with hepatitis C virus chronic infection. Diabetes Care. ,vol. 23, pp. 1177- 1181 ,(2000) , 10.2337/DIACARE.23.8.1177
Javier Bartolomé, Elena Rodríguez-Iñigo, Pedro Quadros, Sonia Vidal, Isabel Pascual-Miguelañez, José Antonio Rodríguez-Montes, Luis García-Sancho, Vicente Carreño, Detection of hepatitis C virus in thyroid tissue from patients with chronic HCV infection. Journal of Medical Virology. ,vol. 80, pp. 1588- 1594 ,(2008) , 10.1002/JMV.21269
Q. Li, B. Xu, S. A. Michie, K. H. Rubins, R. D. Schreriber, H. O. McDevitt, Interferon-α initiates type 1 diabetes in nonobese diabetic mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 12439- 12444 ,(2008) , 10.1073/PNAS.0806439105