A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats
作者： A.J. de Bold , H.B. Borenstein , A.T. Veress , H. Sonnenberg
DOI: 10.1016/0024-3205(81)90370-2
关键词: Atrial natriuretic peptide receptor 、 Urodilatin 、 Atrial natriuretic peptide 、 Homogenization (biology) 、 Endocrinology 、 Alpha-Atrial Natriuretic Peptide 、 Chemistry 、 Reabsorption 、 Internal medicine 、 Atrial volume receptors 、 Low pressure receptor zones 、 General Pharmacology, Toxicology and Pharmaceutics 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: Abstract Supernatants of atrial or ventricular myocardial homogenates were injected intravenously into anaesthetized non-diuretic rats. Extract derived from muscle caused a rapid, more than 30-fold increase sodium and chloride excretions, while urine volume rose 10-fold, potassium excretion doubled. No such changes observed after injection tissue extract obtained the same rat hearts, homogenization medium. There was no significant difference in glomerular filtration rates between two groups. We conclude that contained an extremely powerful inhibitor renal tubular NaCl reabsorption.
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