Macromolecular Transport across Nasal and Respiratory Epithelia

摘要: The airway and alveolar epithelia in conjunction with the mucociliary escalator act as a barrier to prevent translocation of inhaled macromolecules, e.g., protein peptide antigens, across pulmonary surfaces. Nevertheless, some exogenous macromolecules appear cross antigenically intact through either paracellular or transcellular route. Endogenous including albumin, immunoglobulin, lactoferrin, α2-macroglobin, α1antitrypsin have been measured bronchoalveolar lavage fluid liquid that lines surfaces, surface (Mentz et al., 1984; Bignon 1976). These proteins may specialized methods for into out also play significant roles homeostasis, particularly region. Yet knowledge mechanisms responsible maintenance gradients respiratory is primitive relation similar regarding ion gradients.