Radiosterilization dosimetry of vitamins: an ESR study

摘要: Purpose: As an alternative to heat and gas exposure sterilization, ionizing radiation is gaining interest as a sterilization process for medicinal products. Detection dosimetry of pharmaceutical radiosterilization growing concern numerous government regulatory agencies world-wide. Materials methods : Equations describe the ESR curves versus dose storage time were developed using mathematical procedures. For this investigation six vitamins (riboflavin, biotin, thiamine mononitrate, hydrochloride, folic acid pyridoxine) chosen models. Results The yield free radicals in range 1.7 1018-7.3 1019 radicalsmol-1 (G values from 0.0003 0.025 mu mol J-1). Apart qualitative detection, spectrometry can be used estimation; when exponential function applied variation peak-to-peak amplitude on dose, correlates well with data. Tests carried out investigate whether has effect concentr...