From bench to bedside: utility of the rabbit elastase aneurysm model in preclinical studies of intracranial aneurysm treatment

摘要: Preclinical studies are important in helping practitioners and device developers improve techniques tools for endovascular treatment of intracranial aneurysms. Thus an understanding the major animal models used such is important. The New Zealand rabbit elastase induced arterial aneurysm common carotid artery one most commonly testing safety efficacy new devices. In this review we discuss: (1) various to create aneurysm, (2) complications creation, (3) natural history (4) histopathologic hemodynamic features (5) devices tested using model, (6) weaknesses model. We demonstrate how preclinical model applied aneurysms humans. has similar hemodynamic, morphological, histologic characteristics human aneurysms, demonstrates healing responses coiling as Despite these strengths, however, does have many weaknesses, including fact that not emulate complex inflammatory processes affecting growing ruptured Furthermore, extracranial location affects its ability be assessments conclude make it a simple effective on but further work needed develop simulate morphologic