Diversity in the Strength and Structure of Unruptured Cerebral Aneurysms

摘要: Intracranial aneurysms are pathological enlargements of brain arteries that believed to arise from progressive wall degeneration and remodeling. Earlier work using classical histological approaches identified variability in cerebral aneurysm mural content, ranging layered walls with intact endothelium aligned smooth muscle cells, thin, hypocellular walls. Here, we take advantage recent advances multiphoton microscopy, provide novel results for collagen fiber architecture 15 human domes without staining or fixation as well 12 control arteries. For all samples, the elastic lamina was absent abluminal fibers had similar diameters In contrast, on luminal side showed great both diameter dense layers sparse constructs suggestive ineffective remodeling efforts. The mechanical integrity eight samples assessed uniaxial experiments, revealing two sub-classes (i) vulnerable unruptured (low failure stress pressure), (ii) strong (high pressure). These suggest a need refine end-point risk assessment studies currently do not distinguish levels among aneurysms. We propose measure identifies this subpopulation will be useful interpreting future biological structural data.