Impact of transmural heterogeneities on arterial adaptation: application to aneurysm formation.

摘要: Recent experimental and computational studies have shown that transmurally heterogeneous material properties through the arterial wall are critical to understanding expressions of constituent degrading molecules. Given expression such molecules is thought be intimately linked local magnitudes stress, modelling transmural stress distribution adaption during disease. The aim this study was develop an growth remodelling framework can incorporate both distributions residual stresses, into a 3-D finite element model. As illustrative example, we model development fusiform aneurysm investigate effects elastinous collagenous heterogeneities on evolution. It observed adaptive processes exhibit variations. For physiological distributions, peak appears in media towards intima, plateau occurs adventitia. These features primarily attributed underlying heterogeneity constituents. During adaption, collagen strain regulated remain its homoeostatic level; consequently, partial has less influence total than elastin. However, following significant elastin degradation, plays dominant role for profile marked We conclude improve our aetiology disease, there need to: quantify histopathological examinations, understand evolving distribution.