Multi-Scale Modelling of Vascular Disease: Abdominal Aortic Aneurysm Evolution

摘要: We present a fluid-solid-growth (FSG) computational framework to simulate the mechanobiology of arterial wall. The model utilises realistic constitutive that accounts for structural arrangement collagen fibres in medial and adventitial layers, natural reference configurations which are recruited load bearing (normalised) mass-density elastinous collagenous constituents. Growth remodelling (GR quasi-static analysis is employed quantify cyclic deformation vascular cells. apply evolution specific pathology: abdominal aortic aneurysm (AAA). Two illustrative models AAA presented. Firstly, degradation elastin (that observed accompany evolution) prescribed, secondly, it linked low levels wall shear stress (WSS). In first example, we predict development tortuosity accompanies enlargement, whilst latter, illustrate linking WSS leads enlarging fusiform AAAs. conclude this provides basis further investigating elucidating aetiology other diseases. Moreover, has immediate application tissue engineering, e.g., aiding design optimisation engineered constructs.