Transcriptomic Analysis of the Claudin Interactome in Malignant Pleural Mesothelioma: Evaluation of the Effect of Disease Phenotype, Asbestos Exposure, and CDKN2A Deletion Status.

摘要: Malignant pleural mesothelioma (MPM) is a highly aggressive tumor primarily associated with asbestos exposure. Early detection of MPM restricted by the long latency period until clinical presentation, ineffectiveness imaging techniques in early stage and lack non-invasive biomarkers high sensitivity specificity. In this study we used transcriptome data mining order to determine which CLAUDIN (CLDN) genes are differentially expressed as compared controls. Using same approach identified interactome CLDN assessed their expression profile. Subsequently, evaluated effect histology, exposure, CDKN2A deletion status, gender on gene level claudin interactome. We found that 5 out 15 studied CLDNs (4, 5, 8,10,15) 4 27 available interactors (S100B, SHBG, CDH5, CXCL8) were specimens versus healthy tissues. The encoding CLDN-15 S100B proteins present differences profile between three histological subtypes MPM. Moreover, significantly under-expressed cohort patients previous history was also underexpressed lacking gene. These results warrant detailed vitro investigation role CDLN-15 pathobiology