Pleural mesothelial cells in pleural and lung diseases

摘要: During development, the mesoderm maintains a complex relationship with developing endoderm giving rise to mature lung. Pleural mesothelial cells (PMCs) derived from play key role during development of The pleural mesothelium differentiates give endothelium and smooth muscle via epithelial-to-mesenchymal transition (EMT). An aberrant recapitulation such developmental pathways can an important in pathogenesis disease processes as idiopathic pulmonary fibrosis (IPF). PMC is central component immune responses pleura. When exposed noxious stimuli, it demonstrates innate Toll-like receptor (TLR) recognition pathogen associated molecular patterns well causes release several cytokines activate adaptive responses. Development effusions occurs due imbalance dynamic interaction between junctional proteins, n-cadherin β-catenin, phosphorylation adherens junctions PMCs, which caused part by vascular endothelial growth factor (VEGF) released PMCs. PMCs defense mechanisms against bacterial mycobacterial infections, malignant effusion, asbestos related mesothelioma. also resolution inflammation, occur or without fibrosis. Fibrosis result disordered fibrin turnover effects transforming factor-β, platelet-derived (PDGF), basic fibroblast factor; are Recent studies have demonstrated for IPF suggesting their potential cellular biomarker activity possible therapeutic target. Pleural-based therapies targeting treatment other lung diseases need further exploration.