Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases.

摘要: Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional involved both in development and tissue repair, as well pathological processes such cancer metastasis. It has been identified vivo many types of tumours together with its tyrosine kinase receptor, Met. We show here that exogenous HGF/SF acts strong chemoattractant for human mesothelioma cell lines. The also enhanced adhesion to invasion into Matrigel. lines synthesized panel matrix metalloproteinases critical tumour progression MMP-1, 2, 3, 9 membrane-bound MT1-MMP. stimulated the expression MT1-MMP had slight effect on MMP inhibitor TIMP-1 but not TIMP-2. However, there was no simple correlation between levels MMPs TIMPs their different properties or stimulatory effects invasion. In addition, protease inhibitors suggested serine proteases were expressed HGF/SF-induced results predominant role invasion, stimulating simultaneously adhesion, motility, regulation TIMP levels. © 2000 Cancer Research Campaign