Microwave-assisted synthesis of primary amine HX salts from halides and 7 M ammonia in methanol
作者： Mark G. Saulnier , Kurt Zimmermann , Charles P. Struzynski , Xiaopeng Sang , Upender Velaparthi
DOI: 10.1016/J.TETLET.2003.10.146
关键词: Evaporation (deposition) 、 Hydrogen halide 、 Halide 、 Solvent 、 Amine gas treating 、 Ammonia 、 Alkyl 、 Chemistry 、 Inorganic chemistry 、 Organic chemistry 、 Methanol
摘要: Abstract The atom economical synthesis of hydrogen halide salts primary amines, directly from the corresponding halides, avoids production significant amounts secondary amine side products, and requires only evaporation solvent to access products in yields generally greater than 90%. procedure uses microwave irradiation 7 M ammonia methanol (Aldrich) at 130 °C 0.5 2.5 h works on a variety alkyl as well mesylates tosylates. Benzylamines are obtained benzyl halides without that result heating. Direct isolation even highly volatile amines their makes method ideal for use parallel synthesis.
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