Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase.
作者： Mark D. Wittman , Balu Balasubramanian , Karen Stoffan , Upender Velaparthi , Pieying Liu
DOI: 10.1016/J.BMCL.2006.11.041
关键词:
摘要: A novel class of 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors insulin-like growth factor I (IGF-1R) kinase is described. This report discusses the SAR 4-(2-hydroxy-2-phenylethylamino)-substituted pyridones with improved IGF-1R potency.
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