Smart Poly(N-isopropylacrylamide) Containing Iridium(III) Complexes as Water-Soluble Phosphorescent Probe for Sensing and Bioimaging of Homocysteine and Cysteine
作者： Guoyi Cao , Yang Chen , Yun Ma , Yanqin Huang , Xiangmei Liu
关键词: Membrane 、 Cysteine 、 Aqueous solution 、 Iridium 、 Photochemistry 、 Materials science 、 Photoluminescence 、 Amino acid 、 Phosphorescence 、 Poly(N-isopropylacrylamide)
摘要: Homocysteine (Hcy) and cysteine (Cys) are two important kinds of amino acids in human bodies. Herein, we synthesized an iridium(III) complex-functionalized poly(N-isopropylacrylamide) its hydrogel, which could be used as the excellent phosphorescent bioprobe for sensing Hcy Cys. Their detection can realized aqueous system through variations absorption photoluminescence spectra. Furthermore, living cell imaging experiments demonstrate that is membrane permeable monitor changes Cys within cells. In addition, probe also thermoresponsive, intensified with increasing temperature. These results suggests this has promising application biomedical fields.
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