Sympathoadrenergic mechanisms in reduced hemodynamic stress responses after exercise.

摘要: BROWNLEY, K. A., A. L. HINDERLITER, S. G. WEST, GIRDLER, SHERWOOD, and C. LIGHT. Sympathoadrenergic Mechanisms in Reduced Hemodynamic Stress Responses after Exercise. Med. Sci. Sports Exerc., Vol. 35, No. 6, pp. 978 –986, 2003. Purpose: This study examines the acute effects of moderate aerobic exercise on 1) hemodynamic sympathetic activity during behavioral stress 2) -adrenergic receptor responsivity a biracial sample 24 sedentary adults. Methods: Before exercise, blood pressure (BP), impedance-derived cardiovascular measures, plasma norepinephrine (NE) epinephrine (EPI) were assessed mental arithmetic active speech tasks, was using standard isoproterenol challenge procedure. Results: After BP, NE, EPI responses to reduced (0.0001 P 0.08), preejection period (PEP) elongated (P 0.0001), 1- 2-receptor 0.02) enhanced. Approximately 65% prepost mean arterial response difference could be accounted for by changes factors, with change NE PEP being single best predictors. Conclusions: BP are strongly linked decrease drive, as evidenced elongation PEP. Coincident this overall dampening stress, increases cardiac vascular occur. These findings may have important implications future translational studies that seek articulate mechanisms through which regular reduces risks hypertensive coronary heart disease. Key Words: BLOOD PRESSURE, STRESS REACTIVITY, SYMPATHETIC NERVOUS SYSTEM, BETA-ADRENERGIC RECEPTOR, CATECHOLAMINE