Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells.
作者： Koh Katsuda , Masafumi Kataoka , Futoshi Uno , Takayoshi Murakami , Tadashi Kondo
关键词: Caspase 3 、 Poly ADP ribose polymerase 、 Mdm2 、 Caspase 、 Tumor suppressor gene 、 A549 cell 、 Cancer research 、 Biology 、 Cell culture 、 Apoptosis
摘要: … In summary, we showed that ectopic gene transfer of p16 into A549 human NSCLC cells activated caspase-3, which in turn cleaved Rb and MDM2, leading to initiation of the apoptotic …
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