Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells.

摘要: The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, intense activity. purpose this review was to examine original vitro studies carried out cancer cell lines, which reported data about HLA-G expression HIF-1 mediated-HLA-G response hypoxia. impact genomic variability on hypoxia responsive elements (HREs) specific for binding also discussed. Under hypoxia, HLA-G-negative lines might transcribe without translation protein while contrast, HLA-G-positive showed a reduced transcriptional activity level. modulation induced by demonstrated different lines. SNPs rs1632947 rs41551813 located distinct HREs prominent role DNA looping. Our research revealed fine regulation hypoxic conditions through HIF-1, depending cellular type variability. Specifically, found should be future investigations as markers with potential clinical value especially metastatic malignancies.