A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds.
作者： Balaraman Kalyanaraman , Gang Cheng , Micael Hardy , Olivier Ouari , Marcos Lopez
DOI: 10.1016/J.REDOX.2017.09.020
关键词: Signal transduction 、 Cell signaling 、 Glutaminolysis 、 Cancer cell 、 Biology 、 Mitochondrion 、 Reactive oxygen species 、 Cytotoxicity 、 Cytotoxic T cell 、 Cell biology
摘要: … a pyruvate mimic (eg, dichloroacetate) shifts cellular metabolism to OXPHOS [9]. Thus, a … and mitochondrial metabolism. Recent research implicates a key role for mitochondrial complex …
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