3,5,7,3',4'-pentamethoxyflavone, a quercetin derivative protects DNA from oxidative challenges: potential mechanism of action.
作者： Rekha Jakhar , Souren Paul , Young Rong Park , Jaehong Han , Sun Chul Kang
DOI: 10.1016/J.JPHOTOBIOL.2014.01.003
关键词: Quercetin 、 Biology 、 DNA protection 、 DNA 、 Antioxidant 、 Biochemistry 、 Oxidative phosphorylation 、 Comet assay 、 Ligand binding assay 、 DNA damage
摘要: DNA protection is one of the most important strategies in cancer therapy. Since quercetin and its derivatives are found to be potent antioxidant agents, they able scavenge radicals significantly. Therefore, we focused on activity 3,5,7,3′,4′-pentamethoxyflavone (PMF), a derivative isolated from Kaemperia parviflora. Although, PMF was very poor compound, still it could remarkably protect oxidative damage. binding assay showed that bound minor groove DNA, which suggests possible mechanism for protective effects. Cellular toxicity RAW 264.7 macrophages this compound safe therapeutic applications.
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