Acute Myocardial Infarction with Hyperoxemic Therapy (AMIHOT): a prospective, randomized trial of intracoronary hyperoxemic reperfusion after percutaneous coronary intervention.
作者： William W O’Neill , Jack L Martin , Simon R Dixon , Antonio L Bartorelli , Daniela Trabattoni
DOI: 10.1016/J.JACC.2007.01.099
关键词: Medicine 、 Myocardial infarction diagnosis 、 Angioplasty 、 Stent 、 Cardiology 、 Prospective cohort study 、 Myocardial infarction 、 Percutaneous coronary intervention 、 TIMI 、 Internal medicine 、 Conventional PCI
摘要: Objectives This study sought to determine whether hyperoxemic reperfusion with aqueous oxygen (AO) improves recovery of ventricular function after percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). Background Hyperbaric reduces injury and when administered during ischemia-reperfusion. Methods In a prospective, multicenter study, 269 patients anterior or large inferior AMI undergoing primary rescue PCI ( Results At 30 days, the incidence major adverse cardiac events was similar between control AO groups (5.2% vs. 6.7%, p = 0.62). There no significant difference in end points groups. post-hoc analysis, reperfused Conclusions Intracoronary safe well tolerated AMI, but did not improve regional wall motion, ST-segment resolution, final infarct size. A possible treatment effect observed
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