Initial experience with hyperoxemic reperfusion after primary angioplasty for acute myocardial infarction: Results of a pilot study utilizing intracoronary aqueous oxygen therapy

摘要: Abstract Objectives The purpose of this study was to evaluate the feasibility and safety intracoronary hyperoxemic reperfusion after primary angioplasty for acute myocardial infarction (MI). Background Hyperoxemic therapy with aqueous oxygen (AO) attenuates injury preserves left ventricular (LV) function in experimental models MI. Methods In a multi-center patients MI undergoing (PTCA), blood (pO2: 600 800 mm Hg) infused into infarct-related artery 60 90 min intervention. end points were clinical, electrical hemodynamic stability during in-hospital major adverse cardiac events. Global regional LV evaluated by serial echocardiography PTCA, AO infusion, at 24 h one three months. Results Twenty-nine enrolled (mean age: 58.9 ± 12.6 years). performed successfully all cases infusion time: 80.8 18.2 min; mean coronary perfusate pO2: 631 235 Hg). There no events or period. Compared baseline, significant improvement global wall motion score index observed (1.68 0.24 vs. 1.48 0.24, p Conclusions Intracoronary is safe well tolerated PTCA. These preliminary data support need randomized controlled trial determine if enhances salvage improves long-term outcome.