Aqueous Oxygen A Highly O2-Supersaturated Infusate for Regional Correction of Hypoxemia and Production of Hyperoxemia

摘要: Background High levels of hyperoxemia may have utility in the treatment regional tissue ischemia, but current methods for its implementation are impractical. A catheter-based method infusion O 2 , dissolved a crystalloid solution at extremely high concentrations, ie, I to 3 mL /g (aqueous oxygen [AO]), into blood without bubble nucleation was recently developed potential hyperoxemic ischemia. Methods and Results To test hypotheses that hypoxemia is correctable can be produced locally by AO infusion, normal saline equilibrated with MPa (30 bar; /g) delivered arterial two different animal models. In 15 New Zealand White rabbits systemic hypoxemia, infused midabdominal aorta 1 g/min. Mean distal Po increased 236±113 593±114 mm Hg on 1-hour periods air breathing, respectively, from baseline 70±10 (P .05) temporal changes counts chemistries were identified. 10 dogs, low coronary flow circumflex artery roller pump through central channel an occluding balloon catheter. Hypoxemic, normoxemic, AO-induced perfusates (mean 52±4, 111±22, 504±72 Hg, respectively) 3-minute randomized sequence. Short-axis two-dimensional echocardiography demonstrated significant decrease (P<.05) left ventricular ejection fraction compared physiological values low-flow hypoxemic normoxemic perfusion not perfusion. Conclusions Intra-arterial effective these models correction production hyperoxemia.