Detection of papillomaviral DNA sequences in a feline oral squamous cell carcinoma.

作者: J.S. Munday , L. Howe , A. French , R.A. Squires , H. Sugiarto

DOI: 10.1016/J.RVSC.2008.07.005

关键词: PapillomaviridaeNeoplasmPolymerase chain reactionMouth neoplasmFeline Oral Squamous Cell CarcinomaCATSCarcinomaBiologyPathologyDNA sequencing

摘要: Oral squamous cell carcinomas (OSCCs) are common and often fatal feline neoplasms. Factors that predispose to neoplasm development in cats poorly defined. Around 25% of human OSCCs caused by papillomaviruses (PVs). To determine if PVs associated with cats, three sets consensus primers were used evaluate 20 non-neoplastic oral lesions for the presence PV DNA. Papillomaviral sequences detected within one OSCC, but no lesion. Sequencing amplified DNA revealed a previously unreported was most similar type 76. This is first time has been from cavity cat. However, while these results suggest gingival epithelial cells can be infected PVs, they do not support causal association between viral infection OSCCs.

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