New Frontiers in the Design and Synthesis of Imaging Probes for PET Oncology: Current Challenges and Future Directions
作者： Graham Smith , Laurence Carroll , Eric O. Aboagye
DOI: 10.1007/S11307-012-0590-Y
关键词: Medical physics 、 Internal medicine 、 Oncology 、 Pet imaging 、 Medicine 、 Therapy monitoring
摘要: Despite being developed over 30 years ago, 2-deoxy-2-[18F]fluoro-d-glucose remains the most frequently used radiotracer in PET oncology. In last decade, interest new and more specific radiotracers for imaging biological processes of oncologic has increased exponentially. This review summarizes strategies underlying development those probes together with their validation status clinical translation; a brief summary radiochemistry applicable to is also included. The article finishes consideration challenges scientists must overcome bring about adoption as diagnostic or pharmacologic tool.
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