Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding.

摘要: A major subset of non-alloreactive NK cells in PVG strain rats is generally low Ly49 receptors, but expresses the rat NKR-P1BPVG receptor (previously termed NKR-P1C). The NKR-P1B+ inhibited by a non-polymorphic target cell ligand, which we have shown here to be C-type lectin-related molecule (Clr). Clr11 ligates two divergent NKR-P1B alleles as judged an NFAT-driven reporter assay, and inhibits NK-cell cytotoxicity cells. also interacts with prototypic NKR-P1A exerts stimulatory influence on lysis. B are encoded adjacent genes proximal part gene complex show close sequence homology their extracellular region. They diverge from another pair, NKR-P1F -G, second, distal Nkrp1 cluster. -G bind overlapping panel Clr ligands, not Clr11. Rat molecules appear constitutively expressed hematopoietic cells; expression tumor lines more variable. data existence phylogenetic groups NKR-P1 molecules, demonstrate conservation ligand-binding properties independent signaling function.