Sarcopenia and its individual criteria are associated, in part, with mortality among patients on hemodialysis.

摘要: The relative importance of sarcopenia and its individual components as independent predictors mortality in the dialysis population has not been determined. We estimated whole-body muscle mass using pre-dialysis bioimpedance spectroscopy measurements 645 ACTIVE/ADIPOSE-enrolled prevalent hemodialysis patients from San Francisco Atlanta. Low was defined two standard deviations below sex-specific means for young adults NHANES indexed to height2, body weight, surface area, or index. evaluated association (low mass) by four indexing methods, weak hand grip strength, slow gait speed with mortality. Seventy-eight deaths were observed during a mean follow-up 1.9 years. Sarcopenia significantly associated after adjusting covariates. No criteria death, regardless metrics. In contrast, having strength walking adjusted model. Only slowness improved predictive accuracy death an increase C-statistic 0.63 0.68. However, both weakness net reclassification index compared models without performance measures (50.5% 33.7% weakness), whereas size did not. Neither nor low itself better predictor than functional limitation alone receiving hemodialysis. Thus, physical measures, including even adjustment other confounders.