Proanthocyanidin Metabolism, a mini review

作者: Y.Y. Choy , A.L. Waterhouse

DOI: 10.3233/NUA-140038

关键词: ChemistryMini reviewMetabolismProanthocyanidinGut floraBiochemistryPolyphenol

摘要: There is emerging evidence suggesting that consumption of beverage and food rich in polyphenol may offer protective effects against various neurodegenerative, cardiovascular diseases cancers. Proanthocyanidins (PACs) are one the most abundant human diets, but also least absorbed mostly due to their size structure com- plexity. PACs or condensed tannins oligomers polymers monomeric unit flavan-3-ol (+)-catechin (−)-epicatechin. To date, absorption metabolism still remains largely unknown. The aim this mini review was highlight PACs, effect gut sample preparation for analysis. Ultimately, potential bioactivities derived from interaction between metabolites microbiota warrants further investigation.

参考文章(50)
Laurent Y Rios, Richard N Bennett, Sheryl A Lazarus, Christian Rémésy, Augustin Scalbert, Gary Williamson, Cocoa procyanidins are stable during gastric transit in humans The American Journal of Clinical Nutrition. ,vol. 76, pp. 1106- 1110 ,(2002) , 10.1093/AJCN/76.5.1106
Claudine Manach, Augustin Scalbert, Christine Morand, Christian Rémésy, Liliana Jiménez, Polyphenols: food sources and bioavailability The American Journal of Clinical Nutrition. ,vol. 79, pp. 727- 747 ,(2004) , 10.1093/AJCN/79.5.727
Marie-Paule Gonthier, Véronique Cheynier, Jennifer L. Donovan, Claudine Manach, Christine Morand, Isabelle Mila, Catherine Lapierre, Christian Rémésy, Augustin Scalbert, Microbial Aromatic Acid Metabolites Formed in the Gut Account for a Major Fraction of the Polyphenols Excreted in Urine of Rats Fed Red Wine Polyphenols Journal of Nutrition. ,vol. 133, pp. 461- 467 ,(2003) , 10.1093/JN/133.2.461
Sonia Touriño, Jara Pérez-Jiménez, María Luisa Mateos-Martín, Elisabet Fuguet, María Pilar Vinardell, Marta Cascante, Josep Lluís Torres, Metabolites in contact with the rat digestive tract after ingestion of a phenolic-rich dietary fiber matrix. Journal of Agricultural and Food Chemistry. ,vol. 59, pp. 5955- 5963 ,(2011) , 10.1021/JF200159F
Fernando Sánchez-Patán, María Monagas, M. Victoria Moreno-Arribas, Begoña Bartolomé, Determination of Microbial Phenolic Acids in Human Faeces by UPLC-ESI-TQ MS Journal of Agricultural and Food Chemistry. ,vol. 59, pp. 2241- 2247 ,(2011) , 10.1021/JF104574Z
Marie-Paule Gonthier, Jennifer L Donovan, Odile Texier, Catherine Felgines, Christian Remesy, Augustin Scalbert, Metabolism of dietary procyanidins in rats. Free Radical Biology and Medicine. ,vol. 35, pp. 837- 844 ,(2003) , 10.1016/S0891-5849(03)00394-0
Maaike M. Appeldoorn, Jean-Paul Vincken, Anna-Marja Aura, Peter C. H. Hollman, Harry Gruppen, Procyanidin Dimers Are Metabolized by Human Microbiota with 2-(3,4-Dihydroxyphenyl)acetic Acid and 5-(3,4-Dihydroxyphenyl)-γ-valerolactone as the Major Metabolites Journal of Agricultural and Food Chemistry. ,vol. 57, pp. 1084- 1092 ,(2009) , 10.1021/JF803059Z
M. N. Clifford, Diet-derived phenols in plasma and tissues and their implications for health. Planta Medica. ,vol. 70, pp. 1103- 1114 ,(2004) , 10.1055/S-2004-835835
Jeevan K. Prasain, Ning Peng, Yanying Dai, Ray Moore, Alireza Arabshahi, Landon Wilson, Stephen Barnes, J. Michael Wyss, Helen Kim, Ray L. Watts, Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract. Phytomedicine. ,vol. 16, pp. 233- 243 ,(2009) , 10.1016/J.PHYMED.2008.08.006
Angélique Stalmach, William Mullen, Heike Steiling, Gary Williamson, Michael EJ Lean, Alan Crozier, None, Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy Molecular Nutrition & Food Research. ,vol. 54, pp. 323- 334 ,(2010) , 10.1002/MNFR.200900194