Indomethacin-loaded solid lipid nanoparticles for ocular delivery: development, characterization, and in vitro evaluation.
作者： Ketan Hippalgaonkar , Goutham R. Adelli , Kanchan Hippalgaonkar , Michael A. Repka , Soumyajit Majumdar
关键词: Particle size 、 Partition coefficient 、 Pulmonary surfactant 、 Solubility 、 Dispersity 、 Poloxamer 、 Nanoparticle 、 Chemistry 、 Solid lipid nanoparticle 、 Chromatography
摘要: Abstract Purpose: The goal of this study was to develop and characterize indomethacin-loaded solid lipid nanoparticles (IN-SLNs; 0.1% w/v) for ocular delivery. Methods: Various lipids, homogenization pressures/cycles, Tween 80 fraction in the mixture surfactants (Poloxamer 188 80; total surfactant concentration at 1% w/v), pH were investigated preparation IN-SLNs. Compritol® 888 ATO selected as phase IN-SLNs, indomethacin exhibited a highest distribution coefficient solubility phase. Results: Homogenization 15,000 psi 6 cycles resulted smallest particle size. Increase Poloxamer decrease entrapment efficiency (EE). mean size, polydispersity index, zeta-potential, EE optimized formulation 140 nm, 0.16, −21 mV, 72.0%, respectively. IN-SLNs physically stable post-sterilization on storage period 1 month (last timepoint tested). A dramatic in...
sci-hub.se 参考文章(44)
Melike Uner, Gülgün Yener, Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. International Journal of Nanomedicine. ,vol. 2, pp. 289- 300 ,(2007)
Thomas Backensfeld, Bernd W. Müller, Michael Wiese, Joachim K. Seydel, Effect of cyclodextrin derivatives on indomethacin stability in aqueous solution. Pharmaceutical Research. ,vol. 7, pp. 484- 490 ,(1990) , 10.1023/A:1015860531565
Rainer H Müller, Karsten Mäder, Sven Gohla, Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 50, pp. 161- 177 ,(2000) , 10.1016/S0939-6411(00)00087-4
Vobalaboina Venkateswarlu, Kopparam Manjunath, Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. Journal of Controlled Release. ,vol. 95, pp. 627- 638 ,(2004) , 10.1016/J.JCONREL.2004.01.005
K. Manjunath, J.S. Reddy, V. Venkateswarlu, Solid lipid nanoparticles as drug delivery systems. Methods and Findings in Experimental and Clinical Pharmacology. ,vol. 27, pp. 127- 144 ,(2005) , 10.1358/MF.2005.27.2.876286
I Tomida, Roger Guy Pertwee, Augusto Azuara-Blanco, Cannabinoids and glaucoma British Journal of Ophthalmology. ,vol. 88, pp. 708- 713 ,(2004) , 10.1136/BJO.2003.032250
Ali Seyfoddin, John Shaw, Raida Al-Kassas, Solid lipid nanoparticles for ocular drug delivery Drug Delivery. ,vol. 17, pp. 467- 489 ,(2010) , 10.3109/10717544.2010.483257
Annette zur Mühlen, Cora Schwarz, Wolfgang Mehnert, Solid lipid nanoparticles (SLN) for controlled drug delivery – Drug release and release mechanism European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 45, pp. 149- 155 ,(1998) , 10.1016/S0939-6411(97)00150-1
Ghada Abdelbary, Rania H. Fahmy, Diazepam-Loaded Solid Lipid Nanoparticles: Design and Characterization AAPS PharmSciTech. ,vol. 10, pp. 211- 219 ,(2009) , 10.1208/S12249-009-9197-2
Francesco Castelli, Carmelo Puglia, Maria Grazia Sarpietro, Luisa Rizza, Francesco Bonina, Characterization of indomethacin-loaded lipid nanoparticles by differential scanning calorimetry. International Journal of Pharmaceutics. ,vol. 304, pp. 231- 238 ,(2005) , 10.1016/J.IJPHARM.2005.08.011