Long-range enhancers on 8q24 regulate c-Myc
作者： J. Sotelo , D. Esposito , M. A. Duhagon , K. Banfield , J. Mehalko
关键词: Basic helix-loop-helix leucine zipper transcription factors 、 Proto-Oncogene Proteins c-myc 、 Regulation of gene expression 、 Chromatin immunoprecipitation 、 Genetics 、 Transcription (biology) 、 Biology 、 Enhancer 、 Transcription factor 、 Gene
摘要: Recent genomewide association studies have found multiple genetic variants on chromosome 8q24 that are significantly associated with an increased susceptibility to prostate, colorectal, and breast cancer. These risk loci located in a "gene desert," few hundred kilobases telomeric the Myc gene. To date, biological mechanism(s) underlying these associations remain unclear. It has been speculated variant(s) might affect expression by altering its regulation or amplification status. Here, we show enhancer elements present within this region they can regulate transcription of Myc. We also demonstrate one such element physically interacts promoter via factor Tcf-4 binding acts allele specific manner expression.
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sci-hub.se 参考文章(32)
Ritva Karhu, Jorma J. Isola, Olli-P. Kallioniemi, Anne H. Kallioniemi, Eija R. Hyytinen, Teuvo Tammela, Tapio Visakorpi, Ann-Christine Syvänen, Genetic Changes in Primary and Recurrent Prostate Cancer by Comparative Genomic Hybridization Cancer Research. ,vol. 55, pp. 342- 347 ,(1995)
Inken Wierstra, Jürgen Alves, The c-myc promoter: still MysterY and challenge. Advances in Cancer Research. ,vol. 99, pp. 113- 333 ,(2008) , 10.1016/S0065-230X(07)99004-1
Michael L. Cher, Michael L. Cher, William B. Isaacs, G. Steven Bova, Sokhom S. Pin, Dan H. Moore, Peter R. Carroll, Eric J. Small, Jonathan I. Epstein, Ronald H. Jensen, Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping Cancer Research. ,vol. 56, pp. 3091- 3102 ,(1996)
Y. Qin, Long-range activation of Sox9 in Odd Sex (Ods) mice Human Molecular Genetics. ,vol. 13, pp. 1213- 1218 ,(2004) , 10.1093/HMG/DDH141
Ian Tomlinson, Emily Webb, Luis Carvajal-Carmona, Peter Broderick, Zoe Kemp, Sarah Spain, Steven Penegar, Ian Chandler, Maggie Gorman, Wendy Wood, Ella Barclay, Steven Lubbe, Lynn Martin, Gabrielle Sellick, Emma Jaeger, Richard Hubner, Ruth Wild, Andrew Rowan, Sarah Fielding, Kimberley Howarth, CORGI Consortium, Andrew Silver, Wendy Atkin, Kenneth Muir, Richard Logan, David Kerr, Elaine Johnstone, Oliver Sieber, Richard Gray, Huw Thomas, Julian Peto, Jean-Baptiste Cazier, Richard Houlston, None, A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nature Genetics. ,vol. 39, pp. 984- 988 ,(2007) , 10.1038/NG2085
Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, SEARCH collaborators Luccarini Craig 61 Conroy Don 61 Shah Mitul 61 Munday Hannah 61 Jordan Clare 61 Perkins Barbara 61 West Judy 61 Redman Karen 61 Driver Kristy 61, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, Suleeporn Sangrajrang, Valerie Gaborieau, Fabrice Odefrey, Chen-Yang Shen, Pei-Ei Wu, Hui-Chun Wang, Diana Eccles, D Gareth Evans, Julian Peto, Olivia Fletcher, Nichola Johnson, Sheila Seal, Michael R Stratton, Nazneen Rahman, Georgia Chenevix-Trench, Stig E Bojesen, Børge G Nordestgaard, Christen K Axelsson, Montserrat Garcia-Closas, Louise Brinton, Stephen Chanock, Jolanta Lissowska, Beata Peplonska, Heli Nevanlinna, Rainer Fagerholm, Hannaleena Eerola, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, David J Hunter, Susan E Hankinson, David G Cox, Per Hall, Sara Wedren, Jianjun Liu, Yen-Ling Low, Natalia Bogdanova, Peter Schürmann, Thilo Dörk, Rob AEM Tollenaar, Catharina E Jacobi, Peter Devilee, Jan GM Klijn, Alice J Sigurdson, Michele M Doody, Bruce H Alexander, Jinghui Zhang, Angela Cox, Ian W Brock, Gordon MacPherson, Malcolm WR Reed, Fergus J Couch, Ellen L Goode, Janet E Olson, Hanne Meijers-Heijboer, Ans van den Ouweland, André Uitterlinden, Fernando Rivadeneira, Roger L Milne, Gloria Ribas, Anna Gonzalez-Neira, Javier Benitez, John L Hopper, Margaret McCredie, Melissa Southey, Graham G Giles, Chris Schroen, Christina Justenhoven, Hiltrud Brauch, Ute Hamann, Yon-Dschun Ko, Amanda B Spurdle, Jonathan Beesley, Xiaoqing Chen, AOCS Management Group Bowtell David 146 Green Adele 82 deFazio Anna 147 Chenevix-Trench Georgia 82 Gertig Dorota 111 Webb Penny 82, Arto Mannermaa, Veli-Matti Kosma, Vesa Kataja, Jaana Hartikainen, Nicholas E Day, David R Cox, Bruce AJ Ponder, None, Genome-wide association study identifies novel breast cancer susceptibility loci Nature. ,vol. 447, pp. 1087- 1093 ,(2007) , 10.1038/NATURE05887
M. L. Freedman, C. A. Haiman, N. Patterson, G. J. McDonald, A. Tandon, A. Waliszewska, K. Penney, R. G. Steen, K. Ardlie, E. M. John, I. Oakley-Girvan, A. S. Whittemore, K. A. Cooney, S. A. Ingles, D. Altshuler, B. E. Henderson, D. Reich, Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 14068- 14073 ,(2006) , 10.1073/PNAS.0605832103
Tong-Chuan He, Andrew B Sparks, Carlo Rago, Heiko Hermeking, Leigh Zawel, Luis T Da Costa, Patrice J Morin, Bert Vogelstein, Kenneth W Kinzler, None, Identification of c-MYC as a Target of the APC Pathway Science. ,vol. 281, pp. 1509- 1512 ,(1998) , 10.1126/SCIENCE.281.5382.1509
Thomas Ried, Regina Knutzen, Rüdiger Steinbeck, Harald Blegen, Evelin Schröck, Kerstin Heselmeyer, Stanislas du Manoir, Gert Auer, Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes, Chromosomes and Cancer. ,vol. 15, pp. 234- 245 ,(1996) , 10.1002/(SICI)1098-2264(199604)15:4<234::AID-GCC5>3.0.CO;2-2
Scott W. Lowe, Enrique Cepero, Gerard Evan, Intrinsic tumour suppression Nature. ,vol. 432, pp. 307- 315 ,(2004) , 10.1038/NATURE03098