Study design considerations in developmental neurotoxicology.

摘要: It is widely accepted that exposure to environmental factors during development can result in effects other than death, gross structural abnormality, or altered growth. One area of concern the developing nervous system, which may be especially vulnerable perturbation. Testing chemicals for potential developmental neurotoxicity has received a high priority and testing guidelines have been published recently revised by U.S. Environmental Protection Agency. These are based on several principles developed years research. In general, manifestation following depend time at occurs purposes hazard detection, experiments should designed optimize detection neurotoxicity. addition, maternal health interaction with offspring, as well postnatal important design issues neurotoxicology. also doses used multiple measures assessed both genders points life span animal. Finally, litter usually regarded most appropriate statistical unit control genetic factors.